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TCR-engineered NK (TCR-NK) cells

Public Group October 17, 2025

cailynn johnson

However, native NK cells often lack sufficient specificity and persistence for effective solid tumor eradication. TCR-engineered NK (TCR-NK) cells address this critical unmet need by combining NK cell anti-tumor capabilities with the exquisite antigen specificity of T-cell receptors (TCRs). This engineering allows NK cells to recognize MHC-restricted tumor antigens, expanding their targeting repertoire and enhancing precision for safer, more effective cancer immunotherapies.

Transplant Rejection and GvHD

Public Group October 17, 2025

cailynn johnson

Gene therapy is a rapidly developing field that presents previously unheard-of possibilities for the treatment of complicated illnesses. Despite advancements in transplantation, transplant rejection and GvHD remain significant hurdles, leading to patient morbidity and mortality. Current immunosuppressive regimens often lack specificity, resulting in broad immune suppression and associated side effects.


lorettaecto

Store management games offer a unique blend of strategy, resource management, and often, a touch of the absurd. They challenge you to build, optimize, and protect your virtual business, testing your ability to think on your feet and adapt to unforeseen circumstances.


Frankderson

Okay, okay, I know what you're thinking: "Basket Random a store management game? What kind of nonsense is this?"

Phage display peptide library construction

Public Group September 17, 2025

cailynn johnson Phage display peptide library construction for high-affinity ligand selection enables researchers to screen billions of peptide variants for specific binding properties. Using M13 phage formats, both linear and Cys-constrained libraries are built to identify peptides with strong target affinity. This technique supports applications in drug discovery, diagnostics, and protein interaction studies. Proper sequencing and screening strategies ensure reliable results, with lyophilized peptides delivered ready for experimental use.

cailynn johnson

The M13 phage display system for protein interaction studies utilizes filamentous bacteriophages to present peptides or antibodies on coat proteins like pIII and pVIII. This method enables precise mapping of epitopes, identification of ligands, and exploration of receptor binding. Researchers benefit from its versatility in drug discovery, recombinant antibody production, and diagnostic development. Proper phage handling and display system design are essential for reliable and reproducible experimental outcomes.


cailynn johnson

Comprehensive phage analytics for genetic and immunological profiling enable researchers to explore bacteriophage behavior, genome structure, and host interactions. Services include DNA extraction, metagenomic sequencing, and immunogenicity testing using ELISA and MSD platforms. These methods support phage therapy development and microbial research. Accurate sample preparation and purification are essential for reliable results, with biophysical and biochemical assays providing deeper insights into phage stability, virulence, and host specificity.


cailynn johnson Bacteriophage discovery using synthetic biology tools enables researchers to engineer phages with enhanced antibacterial properties. These viruses, which infect specific bacterial hosts, are isolated from environmental or clinical samples and characterized for therapeutic potential. Advanced techniques allow for the creation of supercharged synthetic phages, offering new solutions against multidrug-resistant infections. This approach supports the development of targeted treatments and expands possibilities in microbial control and phage therapy.

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